Method of treating benign prostatic hyperplasia and other...

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A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/203 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2460139

Methods of treatment of benign prostatic hyperplasia and reduction of the level of the prostate specific antigen (PSA) of benign prostate conditions are disclosed. The treatment method includes an initial treatment of patients with orally administration of an initial dosage of about 40 mg 13 cis-retinoic acid daily for a period from about ten days to about twenty days, and followed by a sustaining treatment of the patients with orally administration of a sustaining dosage of about 40 mg 13 cis-retinoic acid about every five to seven days in a sustaining period.

L'invention concerne des méthodes de traitement d'hyperplasie prostatique bénigne et de réduction du niveau d'antigène spécifique de la prostate (PSA) dans des pathologies prostatiques bénignes. Ces méthodes de traitement comprennent un traitement initial des patients consistant à administrer par voie orale un dosage initial d'environ 40mg d'acide 13-cis rétinoïque par jour, pendant une période d'environ dix à environ vingt jours, et suivi par un traitement prolongé des patients avec administration par voie orale d'environ 40 mg d'acide 13-cis rétinoïque environ tous les cinq à sept jours pendant une période prolongée.

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