Rna interference mediated inhibition of protein typrosine...

Details Rna interference mediated inhibition of protein typrosine... Rna interference mediated inhibition of protein typrosine...

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/7088 (2006.01) A61K 31/713 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2471421

The present invention concerns methods and reagents useful in modulating PTP- 1B gene expression and genes involved in the PTP-1B pathway in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to short interfering nucleic acid (siNA), short interfering RNA (siRNA), double- stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against PTP-1B gene expression. The short interfering nucleic acid molecules are useful in the treatment of cancer, inflammation, obesity and insulin resistance (e.g. Type I and Type II diabetes).

L'invention concerne des méthodes et des réactifs utiles dans la modulation de l'expression génique de PTP-1B, ainsi que des gènes impliqués dans la voie de PTP-1B, dans diverses applications, notamment des applications thérapeutiques, diagnostiques, de validation de cible, et de découverte génomique. L'invention concerne en particulier des molécules d'acide nucléique d'interférence court (siNA), d'ARN d'interférence court (siRNA), d'ARN double brin (dsRNA), de micro-ARN (miRNA) et d'ARN court en épingle à cheveux (shRNA) pouvant induire une interférence ARN (RNAi) contre l'expression génique de PTP-B1. Lesdites molécules d'acide nulcéique d'interférence court sont utiles dans le traitement du cancer, des inflammations, de l'obésité et de la résistance à l'insuline (du diabète de type 1 et de type 2, par exemple).

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