Method for inhibition of viral morphogenesis

Details Method for inhibition of viral morphogenesis Method for inhibition of viral morphogenesis

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01) A01N 37/18 (2006.01) A61K 31/365 (2006.01) A61K 38/00 (2006.01) A61K 38/07 (2006.01) C07K 14/08 (2006.01) C12N 7/04 (2006.01) C12N 7/06 (2006.01) C12Q 1/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01) G01N 33/576 (2006.01)

Patent

CA 2136958

Viral morphogenesis, production, release or uncoating can be inhibited by effecting inhibition of prenylation of, or inhibition of post-prenylation reactions of, at least one viral protein. The use of inhibitors of prenylation, and post-prenylation reactions, for example, inhibitors of the mevaloriate and prenyl group synthesis pathways, inhibitors of prenyl group transferases and mimics of the prenylation target CXXX (SEQ ID NO:1) box are disclosed.

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