C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/15 (2006.01) A61K 38/57 (2006.01) C07K 14/81 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2279265
The present invention provides a human cystatin-like protein (CSTIN) and polynucleotides which identify and encode CSTIN. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding CSTIN and a method for producing CSTIN. The invention also provides for agonists, antibodies, or antagonists specifically binding CSTIN, and their use, in the prevention and treatment of diseases associated with expression of CSTIN. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding CSTIN for the treatment of diseases associated with the expression of CSTIN. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding CSTIN.
Cette invention concerne une nouvelle protéine humaine du type cystatine (CSTIN) et des polynucléotides qui identifient et codent CSTIN; des vecteurs d'expression produits par génie génétique et des cellules hôtes qui comprennent les séquences d'acides nucléiques codant CSTIN ainsi qu'un procédé de production de CSTIN; des agonistes, des anticorps ou des antagonistes se liant spécifiquement à CSTIN et leur utilisation dans la prévention et le traitement de maladies associées à l'expression de CSTIN; l'utilisation de molécules antisens vis-à-vis de polynucléotides codant CSTIN pour le traitement de maladies associées à l'expression de CSTIN; et des méthodes de diagnostiques dans lesquelles on utilise le polynucléotide ou des fragments de ce dernier ou encore son complément, et des anticorps se liant spécifiquement à CSTIN.
Bandman Olga
Goli Surya K.
Incyte Pharmaceuticals Inc.
Smart & Biggar
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