C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/21 (2006.01) A61K 39/102 (2006.01) C07K 14/285 (2006.01) C12N 5/10 (2006.01) C12N 15/70 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2370887
The expression of the lipidated form of the peptidoglycan-associated protein (PAL) of gram-negative bacteria is achieved through the use of a plasmid containing a tightly regulated promoter. A bacterial host cell is transformed, transduced or transfected with such a plasmid. The host cell is then cultured under conditions such that the lipidated recombinant PAL is expressed. The lipidated recombinant PAL is included in an antigenic composition administered to a mammalian host to immunize against a gram-negative bacterium.
L'expression de la forme lipidée de la protéine associée à peptidoglycane (PAL) de bactéries Gram négatif s'obtient par l'utilisation d'un plasmide contenant un promoteur régulé de manière très précise. Selon l'invention, on transforme, transduit ou transfecte une cellule hôte bactérienne à l'aide d'un tel plasmide, puis on fait une culture de la cellule hôte dans des conditions favorisant l'expression de la protéine PAL recombinée. Cette protéine PAL est incluse dans une composition antigénique administrée à un hôte mammifère, en vue d'une immunisation de celui-ci contre une bactérie Gram négatif.
American Cyanamid Company
Smart & Biggar
Wyeth Holdings Corporation
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