Crystal of glucokinase protein, and method for drug design...

Details Crystal of glucokinase protein, and method for drug design... Crystal of glucokinase protein, and method for drug design...

C - Chemistry, Metallurgy

12

N

C12N 9/12 (2006.01) C12Q 1/48 (2006.01)

Patent

CA 2490023

Glucokinase is crystallized, the three-dimensional structure thereof is analyzed, and then a compound to be bonded to glucokinase is designed on the basis of the coordinate for the resulting three-dimensional structure. Specifically, glucokinase is freed of a part of amino acid residues being on the N-terminal side thereof, to thereby crystallize it, and the three- dimensional structure of the resulting crystal is elucidated through the X-ray crystallographic analysis thereof.

On cristallise la glucokinase, on analyse sa structure tridimensionnelle, après quoi on élabore un composé à lier à la glucokinase, en fonction des coordonnées pour la structure tridimensionnelle résultante. Plus spécifiquement, la glucokinase est débarrassée d'une partie des restes d'acide aminé se trouvant sur le côté N-terminal de celle-ci, pour le cristalliser, et la structure tridimensionnelle du cristal résultant est élucidée par analyse cristallographique aux rayons X.

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