Trifluoromethylthio (and sulfonyl) derivatives of...

Details Trifluoromethylthio (and sulfonyl) derivatives of... Trifluoromethylthio (and sulfonyl) derivatives of...

C - Chemistry, Metallurgy

07

D

260/201.1

C07D 211/70 (2006.01) C07D 211/38 (2006.01) C07D 211/44 (2006.01) C07D 211/76 (2006.01) C07F 3/02 (2006.01)

Patent

CA 1085823

Abstract of the Disclosure Cyproheptadine derivatives substituted with a trifluoromethylthio or trifluoromethylsulfonyl group in one of the benzo rings and having a hydroxyalkyl or cycloalkyl- alkyl group on the piperidine nitrogen are potent anti- psychotic agents, with a low propensity to induce extra- pyramidal side effects that are experienced with most major tranquilizers. The tranquilizing activity is pre- dominantly in the levorotatory enantiomers, whereas the dextrorotatory enantiomers have anticholinergic activity. Each enantiomer is useful as a source of the other by racemization. The novel compounds are prepared by treat- ment of the corresponding iodo or bromo compound with bis- (trifluoromethylthio) mercury and copper powder.

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