C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) A61K 31/7088 (2006.01) A61P 35/00 (2006.01) C07H 21/04 (2006.01) C12N 15/12 (2006.01)
Patent
CA 2555245
Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression and for promotion of apoptosis are provided. Methods for treatment of diseases, particularly inflammatory diseases and cancers, associated with overexpression or constitutive activation of STAT3 or insufficient apoptosis are also provided.
La présente invention a trait à des composés, des compositions et des procédés pour l'inhibition de l'expression du gène STAT3 humain. Les compositions comprennent des oligonucléotides antisens ciblés vers des acides nucléiques codant pour le gène STAT3. L'invention a également trait à des procédés d'utilisation de ces oligonucléotides pour l'inhibition de l'expression du gène STAT3 et pour la promotion de l'apoptose. L'invention a trait en outre à des procédés pour le traitement de maladies, notamment des maladies inflammatoires et les cancers, associés à la surexpression ou l'activation constitutive du gène STAT3 ou une apoptose insuffisante.
Gowling Lafleur Henderson Llp
Isis Pharmaceuticals Inc.
LandOfFree
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