C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/10 (2006.01) A61K 31/4184 (2006.01) A61K 31/4245 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61P 25/28 (2006.01) C07D 413/10 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2677296
The invention encompasses 2-[4-(imidazolyl)-phenyl]vinyl-heterocycle derivatives which selectively attenuate production of Abeta(1-42) and are useful in the treatment of Alzheimer's disease. Pharmaceutical compositions and methods of use are also encompassed.
L'invention concerne des dérivés de 2-[4-(imidazolyl)-phenyl]vinyl-hétérocycles qui atténuent sélectivement la production d'Abeta(1-42) et qui sont utilisés dans le traitement de la maladie d'Alzheimer. L'invention se rapporte également à des compositions pharmaceutiques et à des procédés d'utilisation de ces dernières.
Fischer Christian
Munoz Benito
Rivkin Alexey A.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
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