Stable solution of reduced coenzyme q

A - Human Necessities – 61 – K

Patent

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A61K 31/09 (2006.01) A23D 9/007 (2006.01) A23K 1/16 (2006.01) A23L 1/30 (2006.01) A23L 2/52 (2006.01) A61K 8/14 (2006.01) A61K 8/34 (2006.01) A61K 9/127 (2006.01) C07C 41/46 (2006.01) C07C 43/23 (2006.01)

Patent

CA 2442151

The present invention provides a composition of a practically usable solution capable of stably maintaining, against oxidation, reduced coenzyme Q, which has not been employed in practice so far because of being liable to undergo oxidation and hydrophobic, a method of preparing the solution and a method of storing the solution. A solution of reduced coenzyme Q which can be stored at a low temperature or room temperature over a long time can be prepared by coating reduced coenzyme Q with liposome made of refined soybean lecithin, etc, and solubilizing, or solubilizing or emulsifying reduced coenzyme Q by using a surfactant at a low temperature.

Selon l'invention, en maintenant la coenzyme Q réduite, qui n'a pas été utilisée dans la pratique jusqu'à présent du fait de sa tendance à l'oxydation et de son caractère hydrophobe, stable contre l'oxydation, on obtient une composition d'une solution de coenzyme Q réduite utilisable en pratique. L'invention concerne par ailleurs un procédé de préparation et un procédé de stockage de cette solution. On peut préparer une solution de coenzyme Q réduite pouvant être stockée à basse température ou à température ambiante pendant une durée prolongée par application sur la coenzyme Q réduite d'un revêtement de liposomes composés de lécithine de soja raffinée, etc. et par solubilisation, ou par solubilisation ou émulsification de coenzyme Q réduite au moyen d'un surfactant en faible concentration.

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