A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/12 (2006.01) A61K 8/04 (2006.01) A61K 31/203 (2006.01) A61K 45/06 (2006.01) A61P 17/10 (2006.01) A61Q 5/00 (2006.01) A61Q 19/00 (2006.01)
Patent
CA 2689662
The invention relates to a composition comprising, in a physiologically acceptable medium, at least one retinoid compound chosen from all-trans retinoic acid, isotretinoin, motretinide, and naphthoic acid derivatives of formula (I), and salts and esters thereof: where R represents a hydrogen atom, a hydroxyl radical, a branched or nonbranched alkyl radical containing from 1 to 4 carbon atoms, an alkoxy radical containing from 1 to 10 carbon atoms or a cycloaliphatic radical which is substituted or unsubstituted, and benzoyl peroxide and also at least one anti-irritant compound chosen from 18.beta.-glycyrrhetinic acid, its salts and its derivatives. The invention is for use in particular in dermatology.
L'invention concerne une composition comprenant, dans un milieu physiologiquement acceptable, au moins un composé rétinoïde choisi parmi l'acide rétinoïque all-trans, l'isotrétinoïne, la motrétinide et des dérivés d'acide naphtoïque représentés par la formule (I), ainsi que des sels et des esters de ceux-ci. Dans ladite formule, R représente un atome d'hydrogène, un radical hydroxyle, un radical alkyle ramifié ou non ramifié contenant de 1 à 4 atomes de carbone, un radical alcoxy contenant de 1 à 10 atomes de carbone ou un radical cycloaliphatique qui est substitué ou non substitué, et du peroxyde de benzoyle et également au moins un composé anti-irritant choisi parmi l'acide 18.beta.-glycyrrhétinique, ses sels et ses dérivés. La composition est destinée à être utilisée en particulier en dermatologie.
Galderma Research & Development
Robic
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