Tricyclic benzazepine vasopressin antagonists

Details Tricyclic benzazepine vasopressin antagonists Tricyclic benzazepine vasopressin antagonists

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) C07D 223/20 (2006.01) C07D 223/28 (2006.01) C07D 243/38 (2006.01) C07D 267/20 (2006.01) C07D 281/16 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07F 9/547 (2006.01)

Patent

CA 2210688

Tricyclic compound of general formula (I) as defined herein which exhibit antagonist activity at V1 and/or V2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and process for preparing such compounds.

L'invention porte sur des composés tricycliques de formule générale (I) présentant une activité antagoniste vis à vis des récepteurs V1 et V2 et une activité in vivo antagoniste de la vasopressine, sur des procédés d'utilisation de ces composés pour le traitement de maladies caractérisées par un excès de réabsorption rénale d'eau et sur un procédé de préparation desdits composés.

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