Assay for emetic activity

Details Assay for emetic activity Assay for emetic activity

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) A61K 49/00 (2006.01) C12Q 1/44 (2006.01)

Patent

CA 2362305

An assay for emetic activity among inhibitors of type 4 phosphodiesterase (PDE 4) is disclosed. The assay comprises: (A) administering to a test mammal an anesthetic compound in an amount sufficient to cause an anesthetic effect; (B) administering to the test mammal a test compound that has PDE 4 inhibitory activity; (C) observing the test mammal for changes in the anesthetic effect, and(D) correlating any change in the anesthetic effect observed in the anesthetized test mammal to a standard.

L'invention a trait à une méthode destinée à l'activité émétique parmi d'inhibiteurs de phosphodiestérase de type 4 (PDE 4). Cette méthode consiste à: (A) administrer à un mammifère test un composé anesthésique en quantité suffisante pour occasionner un effet anesthésique, (B) administrer au mammifère test un composé test qui possède une activité inhibitrice PDE 4, (C) observer les changements de l'effet anesthésique chez ce mammifère, et (D) comparer tout changement de l'effet anesthésique observé chez ce mammifère test anesthésié à une norme.

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