Recombinant antibody-enzyme fusion proteins

Details Recombinant antibody-enzyme fusion proteins Recombinant antibody-enzyme fusion proteins

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 16/30 (2006.01) C07K 17/00 (2006.01)

Patent

CA 2289115

The invention relates to recombinantly produced fusion polypeptides comprising antibody VH and VL sequences operatively linked to a .beta.-lactamase for use in the delivery of cytotoxic drugs to tumor cells.

L'invention porte sur des polypeptides fusionnés produits par recombinaison comportant les séquences V¿H? et V¿L? d'anticorps fonctionnellement liées à une .beta.-lactamase et servant à transférer des substances cytotoxiques à des cellules tumorales.

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