C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/00 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) C07K 16/28 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2323080
The present invention provides a method of increasing the percentage of gamma/delta T-cells in a population of hematolymphoid cells and which gamma/delta T-cells can survive for a prolonged period, comprising: a) contacting a population of hematolymphoid cells with interleukin 12 and a ligand of CD2 which induces responsiveness to interleukin 12; and b) contacting the cells of step (a) with an antibody to CD3 and interleukin-2. The present invention also provides a method of treating cancer, treating an infection, promoting wound healing and enhancing bone marrow engraftment in a subject comprising administering to the subject an effective amount of the cells of this invention.
La présente invention concerne une méthode permettant d'accroître le pourcentage de lymphocytes T gamma-delta dans une population de cellules hématolymphoïdes, lesdits lymphocytes T gamma-delta pouvant survivre sur une durée prolongée, consistant: a) à mettre une population de cellules hématolymphoïdes au contact de l'interleukine 12 et d'un ligand de CD2 induisant la faculté de réponse à l'interleukine 12; et b) à mettre les cellules de l'étape a) au contact d'un anticorps dirigé contre CD3 et l'interleukine-2. La présente invention concerne également une méthode de traitement du cancer ou d'une infection, une méthode favorisant la cicatrisation et facilitant la greffe de moelle osseuse chez un sujet, consistant à administrer au sujet une dose efficace des cellules de l'invention.
Lopez Richard
Negrin Robert
Waller Edmund K.
Borden Ladner Gervais Llp
Emory University
Stanford University
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