A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/05 (2006.01) A61K 31/277 (2006.01) A61K 31/554 (2006.01) A61K 31/56 (2006.01) A61K 45/00 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2712593
Methods are provided for treating conditions characterized by dysfunction in protein homeostasis in a patient in need thereof. A method for treating a condition characterized by dysfunction in protein homeostasis in a patient in need thereof is provided which comprises administering to the patient a proteostasis regulator in an amount effective to improve or restore protein homeostasis, and to reduce or eliminate the condition in the patient or to prevent its occurrence or recurrence. The condition can be a loss of function disorder such as a lysosomal storage disease, or a gain of function disorder such as an aging associated disease.
L'invention concerne des méthodes de traitement d'états pathologiques caractérisés par un dysfonctionnement de l'homéostasie des protéines chez un patient nécessitant un tel traitement. Une méthode de traitement consiste à administrer au patient un régulateur de protéostasie, en quantité efficace pour améliorer ou restaurer l'homéostasie des protéines, et réduire ou supprimer l'état pathologique chez ledit patient, ou prévenir l'apparition ou la récurrence de cet état. L'état pathologique peut être un trouble à perte de fonction tel qu'une maladie de stockage lysosomal, ou un trouble à gain de fonction tel qu'une maladie associée au vieillissement.
Kelly Jeffrey W.
Mu Tingwei
Segatori Laura
Fasken Martineau Dumoulin Llp
The Scripps Research Institute
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