Novel cyclohexane derivatives

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 311/37 (2006.01) A61K 31/135 (2006.01) A61K 31/18 (2006.01) A61K 31/4164 (2006.01) A61K 31/426 (2006.01) A61P 3/06 (2006.01) C07C 233/23 (2006.01) C07D 231/10 (2006.01) C07D 277/22 (2006.01)

Patent

CA 2592367

The invention is concerned with novel hexafluoroisopropanol substituted cyclohexane derivatives of formula (I) wherein Rl to R4, X, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.

L'invention concerne des dérivés de cyclohexane substitués par hexafluoroisopropanol de formule (I), dans laquelle Rl à R4, X, m et n sont tels que définis dans la description et dans les revendications, ainsi que des sels et des esters acceptables sur le plan physiologique de ceux-ci. Ces composés se lient à LXR alpha et LXR bêta et peuvent être utilisés comme médicaments.

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