Cea-expression inhibiting ribozymes and methods for the...

C - Chemistry – Metallurgy – 07 – H

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C07H 21/04 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 16/30 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2439294

The present invention provides a method of treatment or prophylaxis of cancer wherein of carcinoembryonic antigen (CEA) plays a role in a subject in need thereof including administering to the subject 1.an effective amount of an agent capable of inhibiting the expression CEA. The preferred agents include ribozymes. The invention also provides a method of potentiating or enhancing the effect of a cancer treatment including in addition to the cancer treatment administering to a subject in need thereof an effective amount of an agent capable of inhibiting the expression of CEA.

L'invention concerne une méthode de traitement ou de prophylaxie d'un cancer dans lequel l'antigène carcino-embryonnaire (ACE) est présent, jouant un rôle chez un sujet qui en a besoin. Ce procédé consiste à administrer au sujet une quantité efficace d'un agent capable d'inhiber l'expression de l'ACE, les ribozymes étant un type d'agents d'inhibition préférés. L'invention concerne également une méthode de potentialisation ou d'amélioration de l'effet du traitement contre le cancer consistant à administrer, en plus du traitement, une quantité efficace d'un agent capable d'inhiber l'expression de l'ACE à un sujet qui en a besoin.

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