Aqueous suspension preparation for injection, method for...

Details Aqueous suspension preparation for injection, method for... Aqueous suspension preparation for injection, method for...

A - Human Necessities

61

K

A61K 47/08 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 31/245 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2077641

The present invention relates to an aqueous suspension preparation for injection and to a method for producing the same and further relates to the use of said preparation for producing pain relief. The invention particularly relates to a preparation as indicated hereinabove, comprising a water-insoluble local anesthetic and/or narcotic analgesic suspended in an aqeuous medium, which preparation can be succesfully used for epidural and intrathecal pain relief and for conduction anesthesia and infiltration anesthesia. The preparation is stabilized by the addition of a non-ionic surface-active agent in an amount of less than 1 wt.%. The particles of the water-insoluble active agent have a mean particle diameter of less than 20 µm. More than 99% of the particles have a diameter of less than 100 µm and more than 90% have a diameter of less than 50 µm.

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