Rna antagonist compounds for the modulation of pik3ca...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/11 (2006.01)

Patent

CA 2707539

The present invention relates to oligomer compounds (oligomers), which target PIK3CA mRNA in a cell, leading to reduced expression of PIK3CA. Reduction of PIK3CA expression is beneficial for the treatment of certain medical disorders, such as hyperproliferative diseases such as cancer.

La présente invention concerne des composés d'oligomères (oligomères) qui ciblent l'ARNm PIK3CA dans une cellule, ce qui entraîne ainsi une expression réduite de PIK3CA. La réduction de l'expression de PIK3CA est bénéfique pour le traitement de certains troubles médicaux, tels que les maladies hyperprolifératives comme le cancer.

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