A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) C12N 15/861 (2006.01)
Patent
CA 2761183
The invention relates to an oncolytic adenovirus that comprises a sequence that encodes a hyaluronidase enzyme inserted in the genome thereof. This adenovirus is distributed more efficiently through the mass of the tumour and consequently the oncolytic effect is enhanced. Endovenous injection of the oncolytic adenovirus of the invention gives rise to regressions in tumour volume. Therefore, the oncolytic adenovirus of the present invention can be used to treat cancer or a pre-malignant stage thereof.
La présente invention concerne un adénovirus oncolytique qui comprend une séquence codant pour une enzyme hyaluronidase insérée dans son génome. Cet adénovirus se diffuse plus efficacement dans la masse tumorale et par conséquent l'effet oncolytique est accru. En injectant l'adénovirus oncolytique par voie endoveineuse, on obtient des régressions du volume tumoral. L'adénovirus oncolytique selon la présente invention est ainsi utile pour le traitement du cancer ou d'un état pré-malin de ce dernier.
Alemany Bonastre Ramon
Cascallo Piqueras Manel Maria
Guedan Carrio Sonia
Borden Ladner Gervais Llp
Fundacio Privada Institut D'investigacio Biomedica de Bellvitge
Institut Catala D'oncologia
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