Biomarkers for egfr/her/erbb drug efficacy

Details Biomarkers for egfr/her/erbb drug efficacy Biomarkers for egfr/her/erbb drug efficacy

G - Physics

01

N

G01N 33/574 (2006.01) C12Q 1/00 (2006.01) C12Q 1/42 (2006.01) C12Q 1/48 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2722890

The present invention provides biomarkers useful in the de-termination of a cell's sensitivity to an ErbB2 blocking compound, methods of use of the biomarkers and kits comprising tools for detecting the biomarkers. The biomarkers comprise components of the ErbB3/PI3K/Akt and their phophorylated forms.

La présente invention concerne des marqueurs biologiques utiles dans la détermination de la sensibilité d'une cellule à un composé bloquant ErbB2, des procédés d'utilisation des marqueurs biologiques et des nécessaires comprenant des outils pour détecter les marqueurs biologiques. Les marqueurs biologiques comprennent des composants de ErbB3/PI3K/Akt et leurs formes phosphorylées.

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