C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/10 (2006.01) A61K 38/07 (2006.01) C07D 209/20 (2006.01)
Patent
CA 2564613
The present invention relates to novel growth hormone releasing pseudopeptides capable of stimulating the release of growth hormone from the pituitary and of promoting growth in mammals. The invention also provides pharmaceutical compositions comprising the pseudopeptides growth hormone secretagogues and a method for promoting the release of growth hormone in mammals. If continuously administered, the present pseudopeptides may also inhibit the release of growth hormone by down-regulating the growth response. An exemplary pseudopeptide compound of this invention is Aib-D-Trp-D-Trp.psi.[CH2-NH-O]Gly- NH2 (IIa).
La présente invention concerne de nouveaux pseudopeptides libérant l'hormone de croissance, qui sont capables de stimuler la libération de l'hormone de croissance à partir de l'hypophyse et de favoriser la croissance chez les mammifères. Cette invention concerne également des compositions pharmaceutiques comprenant les pseudopeptides sécrétagogues de l'hormone de croissance, ainsi qu'un procédé pour favoriser la libération de l'hormone de croissance chez les mammifères. En administration continue, ces pseudopeptides peuvent également inhiber la libération de l'hormone de croissance en réduisant la réponse de croissance. Aib-D-Trp-D-Trp?[CH¿2?-NH-O]Gly-NH¿2 ?(IIa) est un composé pseudopeptidique tenant lieu d'exemple pour cette invention.
Deghenghi Romano
Goudreau Gage Dubuc
Mediolanum Farmaceutici S.p.a.
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