Genetically engineered retroviral vector particles capable...

Details Genetically engineered retroviral vector particles capable... Genetically engineered retroviral vector particles capable...

C - Chemistry, Metallurgy

12

N

C12N 15/48 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2360858

The present invention is a method of generating retro- viral vector particles derived from retroviruses and capable of transducing therapeutic genes into non-dividing cells. Mutations made in the retroviral matrix protein (MA) enable infection of non-dividing cells.

L'invention concerne une technique de production de particules de vecteur rétroviral dérivées de rétrovirus, et capables de transduire des gènes thérapeutiques en cellules ne se divisant pas. Les mutations de la protéine à matrice (MA) rétrovirale permettent l'infection desdites cellules ne se divisant pas.

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