C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 261/04 (2006.01) A61K 31/41 (2006.01) A61P 29/00 (2006.01) C07D 261/20 (2006.01) C07D 498/10 (2006.01)
Patent
CA 2664247
The present invention relates to catechol derivatives of formula (I), which can be used as inhibitors of phosphodiesterase (PDPI) type 4 or type 7, Compounds disclosed herein can be useful in the treatment of CNS disorders, inflammatory diseases such as, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type 4 or type 7 inhibitors.
La présente invention concerne des dérivés de catéchol pouvant être utilisés en tant qu'inhibiteurs de la phosphodiestérase (PDPI) type 4 ou type 7. Les composés selon l'invention peuvent être utiles dans le traitement des troubles du système nerveux central et de maladies inflammatoires telles que le sida, l'asthme, l'arthrite, la bronchite, la maladie pulmonaire obstructive chronique (MPOC), le psoriasis, la rhinite allergique, le choc, la dermatite atopique, la maladie de Crohn, le syndrome de détresse respiratoire de l'adulte (SDRA), le granulome éosinophile, la conjonctivite allergique, l'arthrose, la colite ulcéreuse et autres maladies inflammatoires, en particulier chez des humains. L'invention concerne également des procédés de préparation de ces composés, ainsi que des compositions pharmaceutiques les contenant et leur utilisation en tant qu'inhibiteurs de la phosphodiestérase (PDE) type 4 ou type 7.
Agarwal Ritu
Balachandran Sarla
Baregama Lalit Kumar
Chakladar Saswati
Dastidar Sunanda G.
Dimock Stratton Llp
Ranbaxy Laboratories Limited
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