Polypeptides of an hdm2 protein-specific murine alpha/beta...

Details Polypeptides of an hdm2 protein-specific murine alpha/beta... Polypeptides of an hdm2 protein-specific murine alpha/beta...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/725 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2445013

The invention relates to polypeptides from a murine .alpha./.beta. T-cell receptor, mediating a hdm2 protein-specific T-cell response, or functional variants or parts thereof, or nucleic acids coding for the above, functional variants, or parts thereof. The effect of the above is that hdm2 protein- expressing cells are recognised by t-cells provided with said genes, cytokines are expressed and a t-cell-induced lysis and/or apoptosis of tumour- or leukaemic-cells is induced.

L'invention concerne des polypeptides d'un récepteur de lymphocytes T .alpha./.beta. des muridés induisant une réponse spécifique de la protéine hdm2 ou de variantes fonctionnelles ou de leurs parties ou des acides nucléiques les codant, des variantes fonctionnelles ou leurs parties. Ils ont pour effet de permettre d'identifier des cellules de lymphocytes T exprimant la protéine hdm2, qui ont été pourvues de ces gènes, d'exprimer de la cytokine et d'obtenir une lyse induite par lymphocyte T et/ou l'apoptose de cellules tumorales ou leucémiques.

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