Nanoparticulate sorafenib formulations

Details Nanoparticulate sorafenib formulations Nanoparticulate sorafenib formulations

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 31/4412 (2006.01)

Patent

CA 2657379

The present invention is directed to compositions comprising a nanoparticulate sorafenib, or a salt, such as a sorfaneib tosylate, or derivative thereof, having improved bioavailability. The nanoparticulate sorafenib particles of the composition have an effective average particle size of less than about 2000 nm and are useful in the treatment of cancer, renal cancer, and related diseases.

La présente invention concerne des compositions comprenant un sorafenib nanoparticulaire, ou un sel, tel que du sorafenib tosylate, ou un dérivé de celui-ci, ayant une biodisponibilité améliorée. Les particules de sorafenib nanoparticulaire de la composition ont une taille effective moyenne des particules inférieure à environ 2 000 nm et elles sont utiles dans le traitement du cancer, du cancer du rein, et de maladies apparentées.

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