Ester combination local anesthetic

Details Ester combination local anesthetic Ester combination local anesthetic

A - Human Necessities

61

K

A61K 31/625 (2006.01) A61F 2/00 (2006.01) A61K 31/135 (2006.01)

Patent

CA 2507511

The present invention provides compositions and methods for improved local anesthesia and/or analgesia, in which onset of action is rapid, the risk of toxicity is low, and the effect is sustained. More particularly, the present invention provides a combination of at least two ester anesthetics for administration to a subject, where at least one ester anesthetic provides a rapid onset of action and at least one ester anesthetic provides sustained activity. The compositions of the present invention are useful for the production of analgesia and/or anesthesia and are particularly useful for the prophylaxis and/or treatment of pain.

L'invention concerne des compositions et des procédés permettant une anesthésie et/ou une analgésie locales améliorées, dans lesquels le délai d'action est bref, le risque de toxicité faible et l'effet prolongé. Plus spécifiquement, l'invention concerne une combinaison d'au moins deux anesthésiques d'ester destinée à être administrée à un sujet, au moins un anesthésique d'ester possédant un délai d'action bref et au moins un anesthésique d'ester présentant une activité prolongée. Les compositions de cette invention sont utiles pour l'analgésie et/ou l'anesthésie et sont plus spécifiquement utiles pour la prophylaxie et/ou le traitement de la douleur.

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