Aziridine derivatives, their production and use

Details Aziridine derivatives, their production and use Aziridine derivatives, their production and use

C - Chemistry, Metallurgy

07

K

C07K 5/00 (2006.01) A61K 31/395 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) C07D 203/06 (2006.01) C07D 203/08 (2006.01) C07D 203/18 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 473/00 (2006.01) C07K 5/02 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2187451

The present invention relates to a compound of formula (I), wherein R1 and Q are independently an optionally esterified or amidated carboxyl group; R2 is hydrogen, an acyl group or an optionally substituted hydrocarbon residue; X is a divalent hydrocarbon residue which may be substituted; or a salt thereof, which is useful as prophylactic and therapeutic agents of bone diseases and as agents for inhibiting thiol protease.

La présente invention concerne un composé ayant la formule (I), dans laquelle R¿1? et Q sont indépendamment un groupe carboxyle éventuellement estérifié ou amidé; R¿2? est de l'hydrogène, un groupe acyle ou un résidu d'hydrocarbure éventuellement substitué; X est un résidu d'hydrocarbure divalent qui peut être substitué; ou un sel de ce dernier, qui peut être utilisé comme agent prophylactique et thérapeutique des maladies des os, et comme agent d'inhibition de la thiol-protéase.

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