Reducing the risk of human and anti-human antibodies through...

Details Reducing the risk of human and anti-human antibodies through... Reducing the risk of human and anti-human antibodies through...

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2564989

The present embodiments relate to methods of identifying and creating human, or humanized antibodies that possess a reduced risk of inducing a Human Anti- Human Antibody (HAHA) response when they are applied to a human host. Other methods are directed to predicting the likelihood of a HAHA response occurring. Methods for screening for anti-HAHA compounds are also included.

La présente invention a trait à des procédés d'identification et de création d'anticorps humains, ou anti-humains présentant le risque d'induction d'une réponse humaine anti-humaine (HAHA) lors de leur application à un hôte humain. D'autres procédés ont trait à la prédiction de la probabilité de la survenance d'une réponse HAHA. L'invention a également trait à des procédés de criblage pour des composés anti-HAHA.

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