Diarylmethyl piperazine derivatives as delta opioid agonists

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 401/10 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 205/04 (2006.01) C07D 209/08 (2006.01) C07D 209/44 (2006.01) C07D 211/26 (2006.01) C07D 213/79 (2006.01) C07D 213/84 (2006.01) C07D 217/04 (2006.01) C07D 231/12 (2006.01) C07D 231/56 (2006.01) C07D 233/54 (2006.01) C07D 249/06 (2006.01) C07D 271/06 (2006.01) C07D 271/10 (2006.01) C07D 271/107 (2006.01) C07D 277/24 (2006.01) C07D 277/56 (2006.01) C07D 401/06 (2006.01) C07D 403/10 (2006.01) C07D 40

Patent

CA 2263957

Compounds of the formula (I) - shown below - are described. (see fig. I) The compounds are useful in the manufacture of a pharmaceutical composition for preventing or treating inflammatory diseases such as arthritis, psoriasis, asthma, or inflammatory bowel disease, disorders of respiratory function, gastro- intestinal disorders such as functional bowel disease, functional GI disorders such as irritable bowel syndrome, functional diarrhoea, functional distension, functional pain, non- ulcerogenic dyspepsia or others associated with disorders of motility or secretion, urogenital tract disorders such as incontinence, as analgesics for treating pain including non- somatic pain, or as immunosuppressants to prevent rejection in organ transplant and skin graft.

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