Method for inhibiting pulmonary oxygen toxicity

A - Human Necessities – 61 – K

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Details

A61K 39/395 (2006.01) A61K 38/02 (2006.01) A61K 38/17 (2006.01) A61P 11/16 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2064604

Disclosed is a prophylactic preparation for inhibit-ing pulmonary oxygen toxicity in a patient requiring elevated levels of oxygen inhalation, which comprises: an effective amount of an agent selected from the group consisting of: a) an antibody capable of binding to ICAM-1; b) a fragment of the antibody (a), the fragment being capable of binding to ICAM-1; c) ICAM-1, being substantially free of natural contami- nants; d) a functional derivative of ICAM-1; e) an antibody capable of binding to a member of the CD18 family of glycoproteins; f) a fragment of the antibody (e), the fragment being capable of binding to a member of the CD18 family of glycoproteins; g) a member of the CD18 family of glycoproteins, being substantially free of natural contaminants; and h) a functional derivative of a member of the CD18 family of glycoproteins in admixture with a pharmaceutically acceptable carrier.

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