C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/04 (2006.01) A61K 31/4164 (2006.01)
Patent
CA 2606110
The present invention provides solid forms of Compound (I), pharmaceutical compositions thereof, and methods for the treatment or prevention of diseases including, but not limited to a liver disease, cancer, a cardiovascular disease, a metabolic disease, a renal disease, an autoimmune condition, an inflammatory condition, macular degeneration, pain and related syndromes, disease-related wasting, an asbestos-related condition, pulmonary hypertension, ischemia/reperfusion injury, central nervous system (CNS) injury/damage or a disease treatable or preventable by the inhibition of JNK. In particular, the invention relates to certain novel crystal forms of the compound l-(5-(lH-l,2,4-triazol-5-yl)(lH-indazol-3- yl))-3-(2- piperidylethoxy)benzene.
L'invention porte sur des formes solides d'un composé (I), sur des compositions pharmaceutiques associées, et sur des procédés de traitement ou de prévention de maladies telles que, entre autres, des maladies du foie, le cancer, des maladies cardio-vasculaires, des maladies métaboliques, des maladies rénales, des conditions auto-immunes, des conditions inflammatoires, la dégénérescence maculaire, la douleur et les syndromes associés, les maladies des avortons, des conditions liées à l'amiante, l'hypertension pulmonaire, les lésions ischémiques/de reperfusion, les lésions/dommages du système nerveux central ou les maladies pouvant être traitées ou prévenues par l'inhibition de JNK. L'invention porte notamment sur certaines formes cristallines nouvelles du composé l-(5-(lH-l,2,4-triazol-5-yl)(lH-indazol-3- yl))-3-(2-piperidylethoxy)benzène.
Ge Chuansheng
Saindane Manohar
Celgene Corporation
Smart & Biggar
LandOfFree
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