C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2267128
A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as PS 112 and transcribed from prostate tissue is described. A fully sequenced clone representing a continuous sequence of PS 112 is also disclosed. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS 112-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS 112 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumours or metastases.
L'invention concerne un ensemble de séquences d'ARN contiguës et partiellement chevauchantes et des polypeptides codés par celles-ci, appelées PS112 et transcrites à partir de tissu de prostate. Un clone entièrement séquencé, représentant une séquence continue de PS112 est également décrit. Ces séquences sont utiles pour détecter, diagnostiquer, évaluer le stade clinique, surveiller, pronostiquer, prévenir ou traiter des maladies et affections de la prostate, tel le cancer de la prostate, et déterminer la prédisposition d'un sujet à de telles maladies et affections. Des anticorps se liant spécifiquement à un polypeptide ou à une protéine codés par PS112, et des agonistes ou des inhibiteurs empêchant l'action du polypeptide PS112 spécifique à un tissu, sont également décrits, ces molécules étant utiles dans le traitement thérapeutique de maladies, tumeurs et métastases de la prostate.
Cohen Maurice
Friedman Paula N.
Gordon Julian
Hodges Steven C.
Klass Michael R.
Abbott Laboratories
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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