Human dickkopf-related protein and nucleic acid molecules...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2366062

Novel Dkk and Dkk-related polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Dkk an Dkk-related proteins, the invention further provides isolated fusion proteins, antigenic peptides and antibodies. The invention also provides Dkk and Dkk-related nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a Dkk and Dkk- related gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

L'invention concerne de nouveaux polypeptides, de nouvelles protéines et de nouvelles molécules d'acide nucléique Dkk et associées à Dkk. En plus de protéines Dkk et associées à Dkk isolées et complètes, l'invention concerne également des protéines de fusion isolées, des peptides antigéniques et des anticorps. L'invention concerne en outre des molécules d'acide nucléique Dkk et associées à Dkk, des vecteurs d'expression recombinants contenant une molécule d'acide nucléique de la présente invention, des cellules hôtes dans lesquelles on a introduit lesdits vecteurs d'expression et des animaux transgéniques non humains dans lesquels un gène Dkk ou associé à Dkk a été introduit ou dissocié. L'invention concerne par ailleurs des méthodes diagnostiques, thérapeutiques et de criblage qui utilisent les compositions de la présente invention.

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