Anti-glypican-3 antibody

Details Anti-glypican-3 antibody Anti-glypican-3 antibody

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2624894

An anti-glypican-3 antibody comprising one or more amino acid substitutions introduced in the Fc region is disclosed. Preferably, in the anti-glypican-3 antibody, one or more of the amino acid residues at the positions 239, 298, 326, 330 and 332 in the Fc region are substituted with other amino acid residues. Since the Fc-modified anti-glypican-3 antibody of the invention exhibit enhanced ADCC activity, it is useful in treating cancers, such as hepatic cancer. Also disclosed are an anticancer agent comprising the anti- glypican-3 antibody of the invention and a pharmaceutically acceptable carrier, as well as a method of treating a patient with cancer comprising administering to the patient the anticancer agent of the invention.

L'invention concerne un anticorps anti-glypicane 3 comprenant une ou plusieurs substitutions d'acides aminés introduites dans la région Fc. De préférence, dans cet anticorps anti-glypicane 3, un ou plusieurs des résidus d'acides aminés aux positions 239, 298, 326, 330 et 332 dans la région Fc sont substitués par d'autres résidus d'acides aminés. Cet anticorps anti-glypicane 3 modifié dans la région Fc présente une activité ADCC améliorée, d'où son utilité pour traiter des cancers, tels que le cancer du foie. L'invention concerne également un agent anticancéreux comprenant l'anticorps anti-glypicane 3 selon l'invention et un support pharmaceutiquement acceptable, ainsi qu'une méthode de traitement d'un patient cancéreux consistant à administrer à ce patient l'agent anticancéreux selon l'invention.

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