Non-immunosuppressant hiv tat

A - Human Necessities – 61 – K

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Details

A61K 39/21 (2006.01) A61K 39/39 (2006.01) C07K 14/16 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2398269

Anti-lentivirus vaccines and immunotherapeutics and methods for preparing and using same are disclosed. The vaccines and immunotherapeutics are produced using non-immunosuppressive lentivirustrans-activator of transcription (Tat) proteins. An associated in vitro ultra-sensitive macrophage Tat bioassay is disclosed for assessing the immunosuppressive qualities of the lentivirus Tat preparations of the present invention. Additionally, a related long-term T4 cell propagation system for characterizing lentivirus Tat is also disclosed. The present invention has additional utility in the treatment and prevention of AIDS.

L'invention concerne des vaccins anti-lentivirus, une substance d'immunothérapie, et des procédés de préparation et d'utilisation de ces vaccins et cette substance. Lesdits vaccins et ladite substance d'immunothérapie sont produits à l'aide d'un trans-activateur de lentivirus immunosuppresseur de protéines de transcription (Tat). L'invention concerne également un biodosage in vitro de macrophages ultrasensibles à Tat permettant d'évaluer les qualités immunosuppressives des préparations de lentivirus Tat. L'invention concerne, en outre, un système de propagation de cellules T4 à long terme permettant de caractériser un lentivirus Tat. Cette invention présente un avantage supplémentaire permettant de traiter et de prévenir le SIDA.

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