Pyrido-pyridazinone acetic acids for treating chronic...

Details Pyrido-pyridazinone acetic acids for treating chronic... Pyrido-pyridazinone acetic acids for treating chronic...

C - Chemistry, Metallurgy

07

D

167/224, 260/264

C07D 471/04 (2006.01) A61K 31/50 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2016326

A series of novel 6-substituted-5-oxo-6H-pyrido- [2,3-d]pyridazine-8-ylacetic acid and 7-substituted- 8-oxo-7H-pyrido[2,3-d]pyridazine-5-ylacetic acid compounds have been prepared, including their C1-C6 alkyl ester derivatives, as well as the base salts of said acids with pharmacologically acceptable cations. Typical member compounds include those acids wherein the ring substituent is always attached to the available ring-nitrogen atom and is either a lower aralkyl group or a lower heteroaralkyl group. These compounds are useful in therapy as aldose reductase inhibitors for the control of certain chronic diabetic complications. Methods for preparing these compounds from known starting materials are provided.

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