Piperazino derivatives as neurokinin antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/12 (2006.01) A61K 31/495 (2006.01) C07D 209/00 (2006.01) C07D 221/00 (2006.01) C07D 223/00 (2006.01) C07D 241/00 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 451/04 (2006.01) C07D 451/06 (2006.01) C07D 453/06 (2006.01) C07D 471/08 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2269128

The invention relates to compounds of formula (I) wherein Z, R c, y, m, u, Ar2, n, X, R c', 1 and Ar2 are as described herein. These compounds are neurokinin antagonists. These compounds are useful in the treatment of chronic airway diseases such as asthma.

La présente invention concerne des composés représentés par la formule générale (I) dans laquelle les symboles Z, Rc, y, m, u, Ar1, n, X, Rc', l et Ar2 sont conformes aux descriptions qu'en donnent les revendications. Ces composés, antagonistes de la neurokinine, conviennent pour le traitement d'affections chroniques des voies aériennes telles que l'asthme.

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