C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/54 (2006.01) A61K 31/415 (2006.01) A61K 31/416 (2006.01) A61K 31/4439 (2006.01) A61K 31/454 (2006.01) A61K 31/5377 (2006.01) A61P 1/04 (2006.01) A61P 1/16 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 19/08 (2006.01) A61P 21/02 (2006.01) A61P 25/00 (2006.01) A61P 25/02 (2006.01) A61P 25/08 (2006.01) A61P 25/14 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61
Patent
CA 2383268
Compounds having activity as selective inhibitors of JNK are disclosed. The compounds of this invention are pyrazoloanthrone and derivatives thereof having structure (I) wherein R1 and R2 are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to JNK inhibition. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.
La présente invention concerne des composés possédant une activité d'inhibiteurs sélectifs de JNK. Les composés sont la pyrazoloanthrone et des dérivés de ce produit présentant la structure (I) dans laquelle R¿1? et R¿2? sont définis dans l'invention. De tels composés permettent de traiter un large domaine de troubles sensibles à l'inhibition de JNK. L'invention concerne donc des méthodes de traitement de tels troubles, ainsi que des compositions pharmaceutiques contenant un ou plusieurs des composés ci-dessus.
Bennett Brydon L.
Bhagwat Shripad S.
Manning Anthony M.
Murray Brion W.
O'leary Eoin C.
Osler Hoskin & Harcourt Llp
Signal Pharmaceuticals Inc.
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