Viable non-toxic gram negative bacteria

Details Viable non-toxic gram negative bacteria Viable non-toxic gram negative bacteria

A - Human Necessities

61

K

A61K 39/00 (2006.01) C08B 37/00 (2006.01) C12N 1/21 (2006.01)

Patent

CA 2637903

The present invention provides non-toxic Gram-negative bacteria. In particular, the present invention provides viable Gram-negative bacteria (e.g., E. coli) substantially lacking lipopolysaccharide (LPS, endotoxin) within the outer membrane. The present invention further provides methods of generating viable non-toxic Gram-negative bacteria and uses thereof. The present invention also provides compositions and methods for inducing immune responses and for researching and developing therapeutic agents.

La présente invention concerne une bactérie à Gram-négatif non toxique. En particulier, la présente invention concerne une bactérie à Gram-négatif viable dont la membrane externe est (par exemple, E. coli) essentiellement dépourvue de lipopolysaccharide (LPS, endotoxine). La présente invention concerne en outre des procédés destinés à générer une bactérie à Gram-négatif viable non toxique et des utilisations de celle-ci. La présente invention concerne également des compositions et procédés destinés à induire des réponses immunitaires et à rechercher et développer des agents thérapeutiques.

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