Nucleic acids, proteins, and antibodies

Details Nucleic acids, proteins, and antibodies Nucleic acids, proteins, and antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12N 9/00 (2006.01) C12N 9/64 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2392438

The present invention relates to novel pancreatic cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "pancreatic cancer antigens", and the use of such pancreatic cancer antigens for detecting disorders of the pancreas, particularly the presence of pancreatic cancer and pancreatic cancer metastases. More specifically, isolated pancreatic cancer associated nucleic acid molecules are provided encoding novel pancreatic cancer associated polypeptides. Novel pancreatic cancer polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human pancreatic cancer associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the pancreas, including pancreatic cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.

L'invention concerne de nouveaux polynucléotides associés au cancer du pancréas et les polypeptides codés par ces polynucléotides désignés ici collectivement par "antigènes du cancer du pancréas", ainsi que l'utilisation de tels antigènes du cancer du pancréas pour détecter des troubles du pancréas, notamment l'existence d'un cancer du pancréas et de métastases du cancer du pancréas. L'invention concerne plus spécifiquement des molécules d'acides nucléiques isolées associées au cancer du pancréas et codant pour de nouveaux polypeptides associés au cancer du pancréas. L'invention concerne aussi de nouveaux polypeptides du cancer du pancréas et des anticorps se liant à ces polypeptides, ainsi que des vecteurs, des cellules hôtes et des méthodes de recombinaison et de synthèse pour produire des polynucléotides ou des polypeptides humains associés au cancer du pancréas. L'invention concerne également des méthodes diagnostiques et thérapeutiques servant au diagnostic, au traitement, à la prévention ou à la prévision de troubles liés au pancréas, notamment du cancer du pancréas. L'invention concerne en outre des méthodes de sélection servant à identifier des agonistes et des antagonistes des polynucléotides et polypeptides selon l'invention. L'invention concerne enfin des méthodes ou des compositions servant à inhiber la production et la fonction des polypeptides selon l'invention.

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