Targeting of alpha-1 or alpha-3 subunit of na+, k+-atpase in...

Details Targeting of alpha-1 or alpha-3 subunit of na+, k+-atpase in... Targeting of alpha-1 or alpha-3 subunit of na+, k+-atpase in...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/429 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2668346

The present invention provides methods, reagents, pharmaceutical formulations and kits for the treatment of proliferative diseases, such as tumours and cancers. The invention teaches to target select subunits of the Na+,K+-ATPase, and especially the alpha-1 subunit and/or the alpha-3 subunit thereof.

L'invention propose des procédés, des réactifs, des formulations pharmaceutiques et des coffrets pour le traitement de maladies prolifératives, telles que les tumeurs et les cancers. L'invention propose de cibler des protomères sélectionnés de la Na+, K+-ATPase, et, en particulier, le protomère alpha-1 et/ou le protomère alpha-3 de celle-ci.

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