Use of thiazolidinediones derivatives for preventing uterine...

A - Human Necessities – 61 – K

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A61K 31/427 (2006.01) A61K 31/426 (2006.01) A61K 31/4439 (2006.01) A61P 15/06 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2348910

The present invention provides methods of preventing or reducing oxytocin- mediated action by using a thiazolidinedione, such as troglitazone, or thiazolidinedione-like compounds. These methods describe the employment of these compounds alone or in combination with at least one other agent, such as a tocolytic agent. This offers a novel therapeutic regimen for the treatment of oxytocin-mediated actions, for example induction of uterine contractions, prostaglandin release, and milk letdown. Accordingly, conditions such as preterm labor and labor prior to Caesarean delivery can be treated by these methods.

La présente invention concerne des méthodes destinées à empêcher ou à réduire une action induite par l'oxytocine grâce à l'emploi d'une thiazolidinédione, une troglitazone par exemple, ou des composés s'apparentant au thiazolidinédione. Ces méthodes font intervenir ces composés soit seuls, soit en combinaison avec au moins un autre agent, tel qu'un agent tocolytique. On dispose ainsi d'un nouveau système de traitement pour les actions induites par l'oxytocine, par exemple les contractions utérines, la libération de prostaglandine ou la descente du lait. Par voie de conséquence, ces méthodes se prêtent au traitement de certains états tel que le travail avant terme et le travail avant accouchement par césarienne.

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