A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/12 (2006.01) A61K 9/00 (2006.01) A61K 9/107 (2006.01) A61K 9/16 (2006.01) A61K 39/21 (2006.01) A61K 39/29 (2006.01)
Patent
CA 2314934
Compositions are provided which include biodegradable microparticles with entrapped or adsorbed antigens, in combination with submicron oil-in-water emulsions. Also provided are methods of immunization which comprise administering to a vertebrate subject (a) a submicron oil-in-water emulsion, and (b) a therapeutically effective amount of a selected antigen entrapped in a microparticle.
L'invention concerne des compositions qui renferment des microparticules biodégradables avec des antigènes piégés ou adsorbés, en combinaison avec des émulsions huile-dans-eau submicroniques. Font aussi l'objet de cette invention des procédés d'immunisation qui consistent à administrer à un patient vertébré a) une émulsion huile-dans-eau submicronique et b) une quantité thérapeutiquement efficace d'un antigène sélectionné piégé dans une microparticule.
O'hagan Derek
Ott Gary S.
Singh Manmohan
Van Nest Gary
Borden Ladner Gervais Llp
Chiron Corporation
Novartis Vaccines And Diagnostics Inc.
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