Combinatorial production of nucleotide and nucleoside...

Details Combinatorial production of nucleotide and nucleoside... Combinatorial production of nucleotide and nucleoside...

C - Chemistry, Metallurgy

07

H

C07H 19/044 (2006.01) A61K 31/7052 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07H 19/052 (2006.01) C07H 19/056 (2006.01) C07H 19/06 (2006.01) C07H 19/16 (2006.01) C07H 21/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) C07B 61/00 (2006.01)

Patent

CA 2411036

The invention concerns novel nucleotide analogues comprising a reactive hydrazide function used as initial synthons for preparing compounds (formula I) capable of inducing mutations or capable of inhibiting a DNA polymerase or a kinase. The invention also concerns nucleic acids comprising said nucleotide and nucleoside analogues. Among such compounds, can be cited in particular the compound of formula (I).

La présente invention concerne de nouveaux analogues de nucléotides comportant une fonction réactive hydrazide servant de synthons de départ pour la préparation de composés (formule I) pouvant induire des mutations ou étant capables d'inhiber une ADN polymérase ou une kinase. L'invention se rapporte également aux acides nucléiques comportant lesdits analogues de nucléosides et nucléotides. Parmi de tels composés, on peut citer notamment le composé de formule (I).

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