C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) A61K 39/39 (2006.01) C07K 14/11 (2006.01) C12N 7/04 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2689569
The present invention provides a linear expression construct free of any conventional amplification and/or selection sequences comprising an RNA polymerase I (poll) promoter and a poll termination signal, inserted between a RNA polymerase Il (polll) promoter and a polyadenylation signal useful for the expression of segments of viral RNA, preferably influenza viruses. The inventive construct is useful for efficient and fast production of viral particles, especially for producing vaccine formulations for the treatment of epidemic and/or pandemic diseases.
La présente invention concerne une construction d'expression linéaire exempte de toute amplification classique et/ou des séquences de sélection comprenant un promoteur d'ARN polymérase I (polI) et un signal de terminaison de polI, introduites entre une ARN polymérase II (polII) et un signal de polyadénylation convenant pour l'expression de segments d'ARN viral, de préférence des virus de la grippe. Cette construction de l'invention convient pour une production efficace et rapide de particules virales, en particulier pour produire des préparations de vaccins destinées au traitement de maladies épidémiques et/ou pandémiques.
Bergmann Michael
Egorov Andrej
Kittel Christian
Muster Thomas
Wolschek Markus
Avir Green Hills Biotechnology Research Development Trade Ag
Sim & Mcburney
LandOfFree
Linear expression constructs for production of influenza... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Linear expression constructs for production of influenza..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Linear expression constructs for production of influenza... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1750406