A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01) A61K 9/28 (2006.01)
Patent
CA 2502915
Methods are disclosed for forming a solid pharmaceutical composition having a desired release profile that include selecting hydroxypropylmethyl cellulose having a particular particle distribution to obtain the desired release profile, and forming a solid pharmaceutical composition comprising a core that comprises a bio-active and the hydroxypropylmethyl cellulose. Solid pharmaceutical compositions are also disclosed that include a bio-active, and hydroxypropylmethyl cellulose having a particle size that is selected to obtain a desired release profile.
L'invention concerne des méthodes de préparation d'une composition pharmaceutique solide présentant un profil de libération désiré. La méthode consiste à choisir de l'hydroxypropylméthyl cellulose présentant une distribution des particules particulière pour créer le profil de libération désiré. La méthode consiste ensuite à former une composition pharmaceutique solide dont le noyau comprend une substance bioactive et de l'hydroxypropylméthyl cellulose. L'invention concerne en outre des compositions pharmaceutiques solides comprenant une substance bioactive, et de l'hydroxypropylméthyl cellulose dont la taille des particules est choisie pour donner un profil de libération désiré.
Holshouser Christopher L.
Leonard Thomas W.
Ponder Garratt W.
Barr Laboratories Inc.
Sim & Mcburney
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