Use of quinazoline derivatives as tyrosine kinase inhibitors...

Details Use of quinazoline derivatives as tyrosine kinase inhibitors... Use of quinazoline derivatives as tyrosine kinase inhibitors...

A - Human Necessities

61

K

A61K 31/505 (2006.01)

Patent

CA 2306155

This invention provides a method of treating or inhibiting colonic polyps in a mammal in need thereof which comprises administering to said mammal a compound having formula (I), wherein X is phenyl which is optionally substituted; R and R1 are each independently, hydrogen, halogen, alkyl, alkoxy, hydroxy or trifluoromethyl; R2 is hydrogen, alkyl, alkoxy, hydroxy or trifluoromethyl; Y is a radical selected from the group consisting of formulae (II), (III), (IV), (V), (VI), (VII) and (VIII). R3 is independently hydrogen, alkyl, carboxy, carboalkoxy, phenyl, or carboalkyl; n = 2-4; or a pharmaceutically acceptable salt thereof, with the proviso that each R3 of Y may be the same or different.

La présente invention concerne le traitement ou la prévention des polypes du colon chez un mammifère. Ce traitement consiste en l'administration au mammifère justifiant d'un tel traitement d'un composé représenté par la formule générale (I). Dans cette formule générale, X est phényle éventuellement substitué. R et R¿1? sont chacun indépendamment hydrogène, halogène, alkyle, alcoxy, hydroxy ou trifluorométhyle. R¿2? est hydrogène, alkyle, alcoxy, hydroxy ou trifluorométhyle. Y est un radical tel que représenté par les formules spécifiques (II), (III), (IV), (V), (VI), (VII) ou (VIII). R¿3? est indépendamment hydrogène, alkyle, carboxy, carboalcoxy, phényle, ou carboalkyle. Le "n" vaut 2 à 4. L'invention concerne également certains des sels de ces composés sous la réserve que chaque R¿3? de Y peut être identique ou différent.

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