A process for stereoselective synthesis of lamivudine

Details A process for stereoselective synthesis of lamivudine A process for stereoselective synthesis of lamivudine

C - Chemistry, Metallurgy

07

D

C07D 411/04 (2006.01) C07D 327/04 (2006.01) A61P 31/18 (2006.01) A61P 31/20 (2006.01)

Patent

CA 2688142

A process for stereoselective synthesis of lamivudine, comprising (a) glycosylation of compounds of formula (I) and cytosine or protected cytosine, separating the resulting products by crystallization to afford intermediates of formula (II); (b) removing the protecting groups of intermediates of formula (II) to obtain lamivudine.

Procédé de synthèse stéréosélective de lamivudine, qui comprend les étapes suivantes: (a) glycosylation de composés de formule (I) et de cytosine ou de cytosine protégée, séparation des produis résultants par cristallisation pour fournir des intermédiaires de formule (II), (b) retrait des groupes protecteurs des intermédiaires de formule (II) pour donner la lamivudine.

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